I like guides. They are really useful for helping to draw, for setting out, for setback lines and so on.
Guides are easy to create. Draw a line or any other object, then go to the Menu bar and choose Modify > Guides > Make Guides. Vectorworks turns your objects into guides, moves them onto a class for you and locks the objects so you do not accidently move or delete them.
You can leave the guides turned on in the design layer for working.
When it comes to a viewport, you can choose to have the guides visible if you want.
Because the guides are on a class, you can choose to have a viewport with the guides turned off. This allows you to work with the guides turned on in the design layer, but the guides will be invisible for printing.